The Science Behind EGF: Your Skin’s Secret Weapon
Written by Kerry Benjamin

In 1986, two pioneering scientists were awarded the Nobel Prize in Medicine for a discovery that would quietly revolutionize skincare. They identified Epidermal Growth Factors (EGFs)—naturally occurring proteins that hold the power to regenerate skin, even after severe damage from burns, sun exposure, or the aging process. Today, EGFs are often called the fountain of youth, and for good reason.
What Are EGFs?
EGFs are powerful proteins produced by fibroblast cells in the skin. Their job? To regulate cellular growth, repair, and renewal. These molecules are essential for maintaining the firmness, elasticity, and smooth texture associated with youthful skin.
By signaling skin cells to produce more collagen and elastin, EGFs help repair damage and reinforce the skin’s structure from the inside out.
How Do EGFs Work?
Think of EGFs as your skin’s natural first responders. When your skin is injured—whether from environmental stress, aging, or acne—EGFs rush in to activate the healing response. They attract cells to the damaged area, prompting a biochemical chain reaction that stimulates tissue repair and cellular regeneration.
The result? Skin that looks smoother, firmer, more radiant—and noticeably younger.
Should You Use Skincare with EGFs?
Absolutely—especially if you're looking to repair, restore, and transform your skin. When applied topically, EGF-infused skincare jumpstarts tissue regeneration and delivers visible results. Clinical studies have shown that EGFs can:
- Reduce pigmentation and age spots
- Minimize fine lines and wrinkles
- Improve skin texture and elasticity
- Firm and tone sagging skin
- Accelerate healing of acne lesions
- Boost collagen production
- Regulate excess oil
- Increase cellular turnover
But here’s where it gets even better…
When you stack EGFs with targeted tools like exfoliation and microneedling, you create a powerful synergy. These treatments physically prep the skin to absorb EGFs more deeply, dramatically amplifying their effects. The result is a complete skin transformation—smoother, firmer, healthier skin that looks as good as it feels.
Ready to adjust your skincare to where your skin is now? Take our quiz to find your personalized Stacked method.
About the Author

Kerry Benjamin, a licensed aesthetician, has over 12 years of experience. Kerry is the driving force behind StackedSkincare. As the company's CEO, Kerry has dedicated her career to revolutionizing skincare. Her innovative approach combines peels, serums, and specialized tools toeffectively address a wide range of skin concerns. CA LE license number Z98459.